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Season 6 of Prison Break was announced in January 2018 at the Television Critics Association winter press tour by Fox Entertainment President Michael Thorn who stated a "new iteration" was in development and "it would not be an entirely new cast."
On March 21, Scheuring tweeted "We're going back to the beginning. Literally the very first frames," and later added "Mahone."
In August 2019, Fox Entertainment CEO Charlie Collier said there were no plans for Prison Break.
“There’s no plan right now to revive Prison Break or any of the other franchises, but when the creators come with a story that they think is the right time to tell, we are so ready to listen because those are some franchises of which I’m so proud and feel so fortunate that they’re in our stable,” Collier said.
In January 2020, Fox Entertainment president Michael Thorn weighed in:
“We continue to talk about 24 and Prison Break as potential spinoffs,” Thorn told Deadline. “There is nothing that is ready to announce..."